Day: October 9, 2024

Critical Update Suggested for Galaxy Z Fold 2 Users

# The Z Fold 2 Receives Its Final Security Update: Implications for Owners

The Samsung Galaxy Z Fold 2, a pioneer in the foldable smartphone arena, has officially come to the conclusion of its software support lifespan. As per a Samsung support site, the device will cease to receive any further software or security updates, with the last security patch issued in August 2024. This signifies the conclusion of an era for the Z Fold 2, which has been a cherished choice among tech fans since its debut in 2020.

In this write-up, we’ll explore what this means for existing Z Fold 2 users, the importance of security updates, and your alternatives going forward.

## Key Information

– **No Further Updates**: The Samsung Galaxy Z Fold 2 will stop receiving software or security updates.
– **Last Security Patch**: The final security update was provided in August 2024, with the last OS upgrade being Android 13 along with One UI 5.1.1 in August 2023.
– **Upgrade Offers**: Samsung is providing a $600 trade-in value for the Z Fold 2, alongside notable discounts on newer foldable devices, particularly during promotions like Prime Day.

## Conclusion of Software Support

The Z Fold 2 has enjoyed a successful lifespan, receiving three significant Android updates and regular security patches. Its last OS upgrade was Android 13 with One UI 5.1.1, which introduced a wide range of new features and enhancements. However, with the August 2024 security update being its final one, the smartphone is now officially out of support from Samsung.

This indicates that any future software vulnerabilities or bugs found will not be addressed, potentially leaving the device at risk of security threats. Although the phone will continue to operate as usual, it will not receive the essential updates that safeguard it from emerging risks.

## Importance of Security Updates

Security updates are arguably more vital than OS updates. While OS updates introduce new functionalities, security patches shield your device from vulnerabilities that hackers or malware could exploit. In an era where smartphones serve multiple purposes, including banking and storing personal data, ensuring your device’s security is paramount.

In the absence of these updates, your Z Fold 2 may gradually become more susceptible as new threats arise. Therefore, it is strongly advised that users consider upgrading to a newer device that continues to receive regular security patches.

## Time to Upgrade: Your Options

If you’re still utilizing a Galaxy Z Fold 2, now is a critical time to think about upgrading. Samsung is providing a **$600 trade-in value** for the Z Fold 2 when transitioning to a newer model, such as the **Galaxy Z Fold 6**, now available at a **historic low price of $1,269** for the 512GB variant. This represents a substantial markdown from its original price of $1,899, offering double the storage of the base model.

### Reasons to Upgrade to the Galaxy Z Fold 6

The Galaxy Z Fold 6 shows considerable advancements compared to the Z Fold 2, presenting:

– **Enhanced Cameras**: Significant enhancements to the camera system, positioning it as one of the top foldable phone cameras available.
– **Streamlined Hinge**: A more sophisticated design featuring a smaller hinge that allows for a completely flat fold.
– **Water and Dust Resistance**: Greater durability with IPX8 water resistance certification.
– **S Pen Compatibility**: Support for the S Pen, making it an excellent choice for both productivity and creativity.
– **Seven Years of Updates**: Samsung now guarantees an impressive seven-year period for OS and security updates, ensuring your device remains secure and current for many years.

### Additional Foldable Alternatives

Though the Galaxy Z Fold 6 is an excellent option, the foldable phone market has significantly grown since the Z Fold 2’s launch. Here are a few other choices to contemplate:

#### 1. **OnePlus Open**
– **Price**: Currently available for **$1,139.99** during Prime Day.
– **Reasons to Consider**: The OnePlus Open features a quicker processor, superior cameras, and broader displays when compared to the Z Fold 2. It also boasts OnePlus’s innovative Canvas design, enhancing multitasking and giving a laptop-like experience when unfolded.

#### 2. **Motorola Razr Plus 2024**
– **Price**: Discounted by **$240** during Prime Day.
– **Reasons to Consider**: For those seeking a more compact option, the Motorola Razr Plus 2024 is an outstanding flip phone choice. It delivers impressive battery performance, a faster processor, and a cover screen that minimizes the need to unfold the device frequently.

## Conclusion: What Should Z Fold 2 Owners Do?

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Samsung Provides Huge Price Cuts on Galaxy Z Fold 6—Enjoy Savings Up to $1,300 This Prime Day

# Secure the Upgrade You Desire at an Incredible Price, No Amazon Prime Membership Required

In the tech marketplace, acquiring the newest gadgets typically comes with a significant cost. Nevertheless, astute shoppers realize that the right timing and deals can create significant savings. If you’re looking to acquire a top-tier foldable smartphone, Samsung has just released a deal that could fulfill your upgrade aspirations—no Amazon Prime membership needed.

## Samsung’s Galaxy Z Fold 6: A Must-Grab Offer You Can’t Overlook

Samsung has introduced a remarkable promotion on its flagship foldable smartphone, the **Samsung Galaxy Z Fold 6**. This offer not only outperforms Amazon’s Big Deals Day sale price by an impressive $130, it also **increases the storage**—providing you with 512GB for the price of the 256GB model. At present, you can purchase the **512GB Galaxy Z Fold 6 for just $1,269** straight from Samsung, contrasting with Amazon’s price of $1,399 for the 256GB version.

### Unique Colors and Aesthetics

To enhance the offer, Samsung is presenting two exclusive colors—**Crafted Black** and **White**—at the best price available. The Crafted Black variant, in particular, shines with its **carbon fiber texture**, imparting a sophisticated, premium touch that tech aficionados will appreciate.

## Trade-In Options: Amplify Your Savings

Samsung is additionally providing **improved trade-in values**, making the deal even more enticing. If you’re keen to upgrade from an older device, you’ll save even further. For instance, if you’re transitioning from a **Galaxy Z Fold 4**, Samsung will grant you up to **$1,000** in trade-in credit. This results in a potential price of the Galaxy Z Fold 6 for as little as **$719**.

In contrast, **Best Buy** continues to offer the 256GB model at the full retail price of **$1,899**, while **Amazon** has it marked down to **$1,399**. Samsung’s deal is clearly the top choice available right now.

## Reasons the Galaxy Z Fold 6 Is Worth Your Investment

The **Samsung Galaxy Z Fold 6** isn’t just another foldable; it’s the pinnacle of what Samsung has created in this category. Here’s why:

### 1. **Sleeker Design**
– The Galaxy Z Fold 6 showcases a **thinner and lighter design** compared to prior models. The revamped hinge allows the phone to fold entirely flat, minimizing the display crease and offering a traditional smartphone feel when closed.

### 2. **Enhanced Longevity**
– For the first time, Samsung has equipped the Galaxy Z Fold 6 with a **dust-resistance rating**, in addition to its water resistance. This positions it as the most robust foldable device Samsung has produced to date.

### 3. **Exceptional Performance**
– Powered by the latest **Qualcomm Snapdragon processor** and abundant RAM, the Galaxy Z Fold 6 guarantees quick performance and seamless multitasking, whether you’re gaming, streaming, or handling work tasks on the move.

### 4. **S Pen Compatibility**
– The redesigned build now supports **S Pen functionality**, making writing and sketching feel more organic than ever. The larger, book-like display offers an enjoyable experience for notes and drawings.

### 5. **Long-Term Software Support**
– Samsung has pledged to deliver **seven years of software updates** for the Galaxy Z Fold 6, ensuring you benefit from updates through **Android 21**. This long-standing support enhances the device’s value, keeping it current with the latest features and security enhancements for years ahead.

## Steps to Claim the Offer

To seize this amazing promotion, navigate to **Samsung.com** and choose the **512GB Galaxy Z Fold 6** in either **Crafted Black** or **White**. This deal comes with an instant **$450 discount**, lowering the price to **$1,269**. If you have an older device for trade-in, you can save even more—up to **$1,300 off** the original price.

### Price Breakdown:
– **Samsung.com**: 512GB Galaxy Z Fold 6 for **$1,269** or as low as **$519** with trade-in.
– **Amazon**: 256GB Galaxy Z Fold 6 for **$1,399**.
– **Best Buy**: 256GB Galaxy Z Fold 6 for **$1,899**.

## Conclusion

If the **Samsung Galaxy Z Fold 6** has caught your attention, now is the ideal time to act. With significant discounts, exclusive colors, and improved trade-in values, Samsung’s offer is truly irresistible.

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“Thinborne Phone Covers: The Sleek Aesthetic That Altered My Perspective, Now Offered at an Incredible Discount”

# Enjoy 35% Discount on Any Thinborne Case This October Prime Day!

If you value a sleek and lightweight phone while still wanting to guard against scratches and everyday wear, **Thinborne** presents the ideal choice for you. This October Prime Day, seize the opportunity to enjoy **35% off** any Thinborne case by entering the exclusive code **AC2024PRIME** at checkout on Amazon. Regardless of whether you have a Samsung, Google Pixel, or iPhone, Thinborne provides ultra-thin aramid fiber cases that deliver excellent grip and scratch defense without adding extra weight to your device.

## Why Opt for Thinborne Cases?

Thinborne cases cater to those who embrace a minimalist mindset towards phone protection. Crafted from **aramid fiber**, this material is renowned for its strength, longevity, and lightweight characteristics. In contrast to bulky cases that can detract from your phone’s sleek appearance, Thinborne cases preserve the original aesthetic and feel of your device while adding essential protection.

### Key Features:
– **Incredibly Slim Design**: Thinborne cases are exceptionally thin, keeping your phone light and manageable.
– **Aramid Fiber Construction**: This advanced material provides outstanding durability and scratch resistance while remaining lightweight.
– **Improved Grip**: The texture of aramid fiber enhances grip, minimizing the chances of accidental drops.
– **MagSafe Compatibility**: Many Thinborne cases include built-in MagSafe magnetic rings, making them ideal for wireless charging and various MagSafe accessories.

### Who Should Purchase Thinborne Cases?
– ✅ **Ideal for**: Individuals who dislike cases that add weight and bulk to their devices. Thinborne cases are a great fit for those wanting to retain their phone’s sleek appearance while enhancing grip and scratch resistance.
– ❌ **Avoid this offer if**: You frequently drop your phone. Thinborne cases aren’t made for heavy-duty drop defense. If you often drop your phone, consider **Caseborne**, Thinborne’s sister brand, which offers enhanced protection.

## Thinborne Cases for Samsung Devices

For Samsung enthusiasts, Thinborne provides a variety of cases for the newest models, including foldable options. Here are some top selections:

– [**Galaxy Z Fold 6**](https://www.amazon.com/dp/B0D7C2QSCP)
– [**Galaxy Z Fold 5**](https://www.amazon.com/dp/B0CHLBZC27)
– [**Galaxy Z Flip 6**](https://www.amazon.com/dp/B0D7C9BLD4)
– [**Galaxy Z Flip 5**](https://www.amazon.com/dp/B0CHGN7Y25)
– [**Galaxy S24 Ultra**](https://www.amazon.com/dp/B0CQL8627X)

## Thinborne Cases for Google Pixel Devices

Google Pixel owners can also take advantage of Thinborne’s ultra-slim cases. These cases are designed for a precise fit with the latest Pixel models:

– [**Pixel 9 and Pixel 9 Pro**](https://www.amazon.com/dp/B0D86S45JD)
– [**Pixel 9 Pro XL**](https://www.amazon.com/dp/B0D868RRWL)
– [**Pixel 9 Pro Fold**](https://www.amazon.com/dp/B0D86M1X4D)
– [**Pixel 8 Pro**](https://www.amazon.com/dp/B0CHL5QFTM)

## Thinborne Cases for iPhone

For iPhone users, Thinborne provides cases that support the latest iPhone models, complete with MagSafe compatibility:

– [**iPhone 15 Series**](https://www.amazon.com/dp/B0CHL686KG)

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Moto G Power 5G Price Cuts to $199 for October Prime Day Event

# Snag a 33% Discount on the Moto G Power 5G (2024) – An Exceptional Smartphone

If you’re searching for an economical smartphone that doesn’t skimp on necessary features, the **Moto G Power 5G (2024)** is a fantastic option. Currently, you can grab this device for just **$199.99**, thanks to a **33% discount** available during Amazon’s Prime Day, cutting its original price from **$299**.

## Why the Moto G Power 5G (2024) is a Smart Buy

The Moto G Power series has a longstanding reputation for striking a great balance between cost and performance, and the 2024 version upholds this legacy with several noteworthy enhancements. Here are some compelling reasons to consider this deal:

### 1. **Outstanding Battery Life**
One of the key highlights of the Moto G Power 5G (2024) is its **impressive 5,000mAh battery**. This allows you to easily navigate through a full day of usage, and potentially longer, without needing to recharge. Whether you’re streaming, browsing, or utilizing apps, this phone is designed for endurance.

### 2. **Rapid Charging**
When it’s time to recharge, the Moto G Power 5G (2024) features **30W fast charging**, enabling you to quickly replenish your battery. This is a notable upgrade for a device in this price bracket, minimizing the time you spend connected to a charger.

### 3. **Robust Performance**
Equipped with the **MediaTek Dimensity 7020 processor** and **8GB of RAM**, the Moto G Power 5G (2024) delivers seamless performance for routine tasks. Whether you’re multitasking, streaming, or engaging on social media, this phone manages it all smoothly.

### 4. **Generous Storage with Expandability**
The device offers **128GB of onboard storage**, which is sufficient for most users. However, if you require additional space for apps, photos, or videos, the Moto G Power 5G (2024) allows for expandable storage via a microSD card, giving you the flexibility to increase your storage as necessary.

### 5. **Android 14 Right Out of the Box**
Another benefit is that this phone comes pre-installed with **Android 14**. This ensures you’ll enjoy the latest features and security enhancements from Google, keeping your device updated and secure.

### 6. **NFC and Wireless Charging**
Interestingly, for a budget device, the Moto G Power 5G (2024) includes **NFC support**, which facilitates easy contactless payments and various NFC-related functions. Moreover, the phone supports **wireless charging**, a feature usually found in more premium devices.

### 7. **Camera Features**
The Moto G Power 5G (2024) boasts a **50MP wide-angle camera** and an **8MP ultra-wide camera**, making it adaptable for capturing different types of images. On the front, it features a **16MP selfie camera**, ideal for video calls and self-portraits. While it may not compete with flagship models in terms of camera performance, it offers solid capabilities for its price point.

### 8. **Aesthetic and Durability**
The phone incorporates a **vegan leather back**, providing a premium feel despite its budget-friendly price. It is also **water-repellent**, adding some protection against splashes and light rain, making it a resilient choice for everyday usage.

## Who Should Consider the Moto G Power 5G (2024)?

### ✅ **Ideal for:**
– Those seeking a **cost-effective phone** with reliable performance and extended battery life.
– Anyone needing a device with **expandable storage** and decent camera functionalities for casual photography.
– Individuals looking for a phone with **NFC** for contactless payments and **wireless charging** for added convenience.
– **Prime members** eager to capitalize on the current **33% discount**.

### ❌ **Consider skipping this deal if:**
– You can invest in a **higher-end phone** with superior cameras and enhanced gaming performance.
– You prioritize **flagship features** like premium cameras or ultra-fast processors.

## How to Claim the Deal

To take advantage of this **33% discount** on the Moto G Power 5G (2024), you’ll need to be an **Amazon Prime member**. The phone is sold in **Midnight Black** and **Pale Lilac**, and you can purchase it directly from Amazon. Note that this promotion is part of Amazon’s **October Prime Day**, which concludes tonight at midnight, so act quickly to secure your purchase!

###

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Samsung Provides $700 Off The Frame TV for Prime Day, Along with a Complimentary Soundbar

# The Sale is Ending Soon — Hurry to Catch Samsung’s Top Offers!

Time is running out, as Samsung’s **anti-Prime Day sale** concludes at midnight tonight. If you’re seeking advanced technology, this is your final opportunity to capitalize on some of the year’s finest bargains. From breathtaking 4K TVs to foldable smartphones and projectors, Samsung is reducing prices on its premium products. However, one particular offer shines brighter than the rest: a **$700 discount on the 75-inch The Frame TV**, along with a **FREE S-Series Dolby Atmos soundbar** worth $349.99.

## Reasons to Snag This Deal

Samsung’s **The Frame TV** transcends the conventional television; it’s a true masterpiece. This elegant, 75-inch QLED 4K TV not only provides an exceptional viewing experience but can also morph into a piece of art when not in use. With its **Quantum Processor 4K** and **AI-enhanced technology**, The Frame guarantees outstanding picture clarity, making it ideal for movie nights, sports, and gaming sessions.

What differentiates The Frame is its aesthetic appeal. The TV boasts a **slim, flush-mount design** that seamlessly integrates into your home decor. You even have the option to personalize the bezel to complement your living space. Additionally, its **anti-glare matte finish** ensures an uninterrupted viewing experience free from reflections, even in well-lit environments.

And if the $700 discount wasn’t compelling enough, Samsung is further enhancing the offer by including a **FREE S-Series Dolby Atmos soundbar**, which usually retails for $349.99. This soundbar provides immersive, cinematic audio, making it the perfect addition to your new television.

### Highlights of The Frame TV:
– **75-inch QLED 4K display** with exceptional picture precision
– **Quantum Processor 4K** for AI-driven performance
– **Art Mode**: Exhibit your favorite artworks when the TV is not active
– **Customizable bezel** to blend with your home aesthetics
– **Anti-glare matte finish** for distraction-free viewing
– **Flush-mount build** for a chic, contemporary look

### Why the Complimentary Soundbar is a Game-Changer:
The **S-Series Dolby Atmos soundbar** elevates your viewing experience by offering deep, immersive sound. Whether enjoying films, gaming, or streaming music, the soundbar’s **Dolby Atmos technology** generates a three-dimensional audio environment that fills the entirety of the room. With this soundbar included at no extra cost, you’re securing a comprehensive home theater setup at an incredible price.

## How to Claim the Offer

To seize this fantastic deal, visit Samsung’s official website before midnight tonight. The **75-inch The Frame TV** is currently listed at **$2,299.99**, reduced from an original price of **$2,999.99**. Add the TV to your shopping cart, and Samsung will automatically provide the **FREE S-Series Dolby Atmos soundbar**.

### Links to the Offer:

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Analysis Shows Noticeable Drop in M4 iPad Pro Demand, Possibly Connected to Pricing Concerns

# The M4 iPad Pro: Examining Demand Trends and Pricing Issues

The M4 iPad Pro was released earlier this year, highlighting notable technological innovations and a lofty price point that has generated both enthusiasm and apprehension among buyers. However, recent data suggests that interest in these premium models has significantly waned, prompting discussions about the viability of such high price points within the tablet sector.

## An In-Depth Examination of Demand Reductions

As per a report from Ross Young, a supply chain analyst at Display Supply Chain Consultants (DSCC), the initial excitement surrounding the M4 iPad Pro has not resulted in ongoing demand. The new models, released in May, initially displayed promise with impressive sales numbers. Nevertheless, subsequent shipment reports of display panels have captured a concerning pattern: a considerable downturn in anticipated demand.

Young’s insights indicate that while earlier estimates projected as many as 10 million panel shipments for 2024, the actual output may be closer to 7 million. This decline is particularly noticeable for the 13-inch model, which has experienced a more dramatic fall in demand compared to its 11-inch sibling.

### Elements Affecting Demand Decrease

1. **Sensitivity to Pricing**: Starting at $1,299, the 13-inch iPad Pro demands a significant expenditure from consumers. The 11-inch model, though not cheap at $999, presents a more appealing upgrade thanks to its new OLED display, representing a clear advancement from the prior LCD technology.

2. **Value Perception**: In spite of the impressive tech enhancements, including the M4 chip and a sophisticated display, numerous consumers regard the iPad as more of a luxury good than a necessity. For those who do not utilize a tablet as their main computing device, the elevated price can deter purchase.

3. **Product Positioning**: The iPad Pro is frequently perceived as a ‘nice to have’ instead of a must-have item, especially when juxtaposed with the essential nature of devices like the iPhone or Mac. This mindset can greatly influence buying choices, particularly for consumers mindful of their budget.

## The Pricing Challenge

The significant price hike for the M4 iPad Pro models has caused trepidation among prospective buyers. Although the technological enhancements are impressive, the reality is that many users might not consider the value proposition sufficient enough to warrant spending upwards of $1,000. For individuals not using the iPad as a laptop substitute, the price can appear excessive, especially considering additional costs for accessories such as the Magic Keyboard and Apple Pencil Pro.

### The Consumer Viewpoint

As Young emphasizes, unless the iPad is being utilized as a primary computer, the pricing can represent a considerable hurdle. The upgrades on the iPad Pro, though remarkable, may not appeal to the average consumer seeking a practical and reasonably priced tablet experience.

## Existing Market Prospects

For those intrigued by the M4 iPad Pro but hindered by its cost, there are currently a few limited-time promotions available on websites such as Amazon. These reductions could offer consumers an opportunity to obtain the device at a more manageable price.

If you are uncertain about which model to select, various resources can assist potential buyers in making an educated choice based on their requirements and preferences.

## Conclusion

The initial achievements of the M4 iPad Pro have been overshadowed by a notable drop in demand, largely linked to its premium pricing and the perceived value by consumers. As Apple tackles these hurdles, comprehending market dynamics and consumer inclinations that impact buying behaviors will be paramount. Whether the price continues to be a significant obstacle to demand will ultimately dictate the future of the iPad Pro series and its standing in the competitive tablet landscape.

Do you concur with Young’s assessment regarding the pricing influence on the iPad Pro’s demand? Share your opinions in the comments below.

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“Prime Day Deals: Savings on Black Titanium Apple Watch Ultra, AirPods, and Additional Items at 9to5Mac”

# Amazon’s Autumn Prime Day Event: Unmatched Offers and Reductions

As we enter the latter part of October, Amazon’s eagerly awaited Autumn Prime Day event is currently taking place, providing consumers with an abundance of offers across a diverse array of products. This year, the event has rolled out notable price reductions on some of the most desirable tech devices, making it a perfect opportunity for shoppers to enhance their gadgets or pick up presents ahead of the festive season.

## Key Features of the Autumn Prime Day Event

### 1. **Apple Watch Ultra 2 at an Unprecedented Low Cost**
One of the highlight bargains this Autumn Prime Day is the new black titanium Apple Watch Ultra 2, now available for an astonishing **$729.99**. This pricing marks the lowest ever documented for this model, which initially retailed at **$799**. Customers can select from a variety of bands, including the Black Trail Loop and Dark Green Alpine Loop, making it an adaptable option for fitness fans and technology aficionados alike.

### 2. **Discounts on M3 MacBook Air Models**
Apple’s newest M3 MacBook Air is also enjoying substantial price cuts. The 13-inch versions can be purchased for as little as **$849**, while the 15-inch setups are currently priced at **$1,044** for the 8GB/256GB variant and **$1,424** for the 16GB/512GB version. These savings can reach up to **$275**, making it a prime moment to invest in a new laptop.

### 3. **AirPods Pro 2 with USB-C MagSafe Case**
For sound enthusiasts, the AirPods Pro 2 featuring the USB-C MagSafe case is now priced at **$168.99**, reduced from the standard price of **$249**. This offer aligns with the best price ever recorded on Amazon, making it essential for anyone wishing to elevate their audio experience.

### 4. **Substantial Discounts on iPad Pro Models**
Amazon is providing **$150 off** on all 256GB and 512GB M4 iPad Pro configurations, with prices commencing at **$849**. This is a fabulous opportunity for those in search of a robust tablet for professional tasks, education, or creative endeavors.

### 5. **New USB-C AirPods Max**
The recently launched USB-C AirPods Max are now accessible for **$499.99**, down from **$549**. This reduction signifies a notable **$49** discount, making it an excellent opportunity for over-ear headphone enthusiasts to upgrade.

### 6. **Beats Studio Buds+ and Solo Buds Offers**
The Beats Studio Buds+ are currently priced at **$119.99**, while the brand-new Beats Solo Buds can be yours for just **$49.99**. These deals reflect significant savings and are ideal for music fans seeking premium audio on the go.

## Other Deals to Consider

– **Level Lock+ Smart Lock**: Now priced at **$129.99**, down from **$329**.
– **Twelve South HiRise 3 Deluxe MagSafe Stand**: Offered at **$106.49**, a 30% reduction from its regular price.
– **Eve Flare Portable Smart HomeKit Lamp**: Now **$74.95**, reduces from **$100**.

## Final Thoughts

Amazon’s Autumn Prime Day event is shaping up to be a bonanza of price cuts, particularly on trendy tech items from Apple and Beats. Whether you’re aiming to upgrade your personal gadgets or searching for the ideal gift for a loved one, now is the moment to seize these time-limited offers. With prices reaching unprecedented lows, shoppers can take advantage of considerable savings while securing the latest technological advancements on the market. Don’t let these fantastic deals slip away as the event goes on!

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Nobel Prize Granted for Advancement in Protein Structure Forecasting

# Nobel Prize in Chemistry 2024: Celebrating Innovations in Computational Chemistry and AI

On Wednesday, the Nobel Committee unveiled the winners of the 2024 Nobel Prize in Chemistry, acknowledging researchers who have made significant strides in the realm of computational chemistry. Featured among the laureates are two scientists from Google’s DeepMind, Demis Hassabis and John Jumper, honored for their groundbreaking efforts in crafting artificial intelligence (AI) software adept at predicting the three-dimensional formations of proteins based on their amino acid sequences. Furthermore, David Baker from the University of Washington received accolades for his progress in architecting entirely new proteins with designated structures through computational methods.

This year’s award signifies a notable trend within the scientific landscape, as AI increasingly assumes a critical role in addressing intricate challenges across various fields. Remarkably, this announcement comes on the heels of the 2024 Nobel Prize in Physics, which similarly acknowledged advancements in AI, albeit with a less direct correlation to the physics domain. In stark contrast, the chemistry accolade makes clear the substantial influence these AI-driven innovations have had on biochemistry, particularly in the realm of comprehending and manipulating protein structures.

## The Significance of Protein Structure

Proteins serve as the essential workhorses of biological systems. They execute a wide range of tasks within cells, from facilitating biochemical reactions (as enzymes) to offering structural support, transporting molecules, and regulating cellular functions. A protein’s role is deeply intertwined with its three-dimensional structure, which is dictated by the sequence of amino acids forming the protein.

From a chemical perspective, proteins are linear sequences of amino acids, with living organisms generally utilizing 20 distinct amino acids to construct these sequences. Each amino acid possesses unique chemical characteristics—some are acidic, others are basic; some harbor positive or negative charges, while a few are neutral. These attributes affect the interactions among different segments of the amino acid chain, prompting the protein to adopt a particular three-dimensional shape. This folding is crucial since a protein’s configuration governs its functionality. Improperly folded proteins can result in illnesses such as Alzheimer’s, Parkinson’s, and cystic fibrosis.

For years, forecasting how a protein would fold based solely on its amino acid sequence was among the most formidable challenges in biochemistry. While methodologies like X-ray crystallography and cryo-electron microscopy could ascertain protein structures, these techniques are labor-intensive, costly, and not universally applicable to all proteins. Computational methods to estimate protein structures had been explored, but they frequently failed to accurately represent the intricacies of protein folding.

## DeepMind’s Breakthrough with AlphaFold

DeepMind, a division of Alphabet (the parent company of Google), had already garnered recognition for creating AI systems that excelled at intricate games like chess and *StarCraft II*. Nevertheless, the organization was also tackling more substantial scientific dilemmas simultaneously. In 2020, DeepMind made headlines announcing that its AI system, AlphaFold, had attained a significant breakthrough in predicting protein structures—a conundrum that had perplexed scientists for years.

AlphaFold employs deep learning, a branch of machine learning, to predict the three-dimensional formation of a protein based on its amino acid sequence. The AI system was trained using an extensive dataset of known protein structures, enabling it to grasp the complex relationships between amino acid sequences and their associated folded forms. When AlphaFold was evaluated in the Critical Assessment of Structure Prediction (CASP) competition, a biennial event that assesses the precision of protein structure prediction methods, it surpassed all other methodologies by a wide margin.

AlphaFold’s achievement revolutionized the domain of structural biology. It furnished researchers with an effective tool to rapidly and accurately forecast protein structures, diminishing reliance on tedious experimental procedures. This breakthrough holds immense potential for drug discovery, disease research, and biotechnology, as discerning protein structures is fundamental for developing new therapeutics and comprehending biological functions at the molecular level.

## David Baker and Protein Design

While AlphaFold concentrates on forecasting the structures of naturally occurring proteins, David Baker’s research at the University of Washington adopts a distinct tactic: engineering entirely new proteins from scratch. Baker’s laboratory created a software platform known as Rosetta, which empowers researchers to design proteins with specified structures and functionalities. This capability paves the way for exciting prospects in creating customized proteins that do not occur naturally but could be beneficial in medicine, industry, and environmental science.

For instance, Baker’s team has engineered proteins capable of binding to specific molecules, such as viral proteins, with high accuracy. This could lead to novel antiviral treatments or diagnostic tools. Moreover, bespoke enzymes might be employed to enhance the efficiency of chemical reactions or to decompose environmental pollutants.

Baker’s endeavors signify a notable advancement in synthetic biology, where the mission is to design biological systems with innovative traits. By developing proteins with tailored functionalities, scientists can forge new instruments for biotechnology, medicine, and ecological sustainability.

## The Role of AI in Scientific Discovery

The 2024 Nobel Prize in Chemistry underscores the expanding role of AI in

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NOAA Commemorates Deceased Scientist by Dispersing Ashes in the Center of Category 5 Hurricane Milton

A Journey Through Hurricane Research: The Legacy of Peter Dodge

Peter Dodge, an innovative radar scientist whose career encompassed years of pioneering hurricane research, left us on March 3, 2023. His collaboration with the National Hurricane Center (NHC) and the Aircraft Operations Center (AOC) created a lasting impact on meteorology, especially in hurricane studies. Dodge’s efforts in both terrestrial and airborne radar research have significantly advanced our comprehension of these formidable storms, and his influence remains vital in current hurricane forecasting and preparedness initiatives.

### A Career at the Center of Meteorological Research

Dodge’s professional journey was deeply connected with the National Oceanic and Atmospheric Administration (NOAA), where he extensively engaged with the Atlantic Oceanographic and Meteorological Laboratory (AOML). His proficiency in radar technology established him as a pivotal figure in the realm of hurricane research, especially in the evaluation of radar data obtained during hurricane reconnaissance flights. Per AOML’s January–March 2023 [newsletter](https://www.aoml.noaa.gov/wp-content/uploads/2023/05/Jan-Mar-2023-AOML-Keynotes-Newsletter.pdf), Dodge was involved in numerous hurricane aircraft missions, taking on the vital role of onboard radar scientist. His responsibilities included performing real-time radar analysis during flights into hurricane centers, a demanding task that required both technical acumen and exceptional bravery.

As his career advanced, Dodge became well-known for his talent in processing and interpreting radar data, which is essential for grasping the structure and intensity of hurricanes. His contributions enhanced the precision of hurricane forecasts, ultimately safeguarding lives by enabling earlier and more accurate storm warnings.

### An Enthusiasm for Radar Innovation

Dodge’s peers at AOML fondly recalled his immense passion for radar technology. He was recognized for his eagerness to discuss not only the latest advancements in radar science but also a myriad of topics such as current affairs, literature, and music. His intellectual curiosity and commitment to his work made him a cherished member of the meteorological community.

Beyond his hands-on involvement during hurricane missions, Dodge played a significant role in devising flight modules for hurricane landfall experiments. These studies were designed to collect data that could enhance our understanding of hurricanes’ behavior as they near and strike land, which is crucial for reducing the effects of these catastrophic events. Even as his vision diminished in later years, Dodge remained an active contributor by collaborating with research teams and overseeing the setup of mobile weather platforms.

### Acknowledged for Outstanding Contributions

Dodge’s impact on hurricane research was widely recognized. Throughout his career, he garnered several esteemed awards, including the Department of Commerce Bronze Medal, two NOAA Administrator Awards, and the Army Corps of Engineers Patriotic Civilian Service Award. Such honors reflect the high esteem in which Dodge was held by both colleagues and the broader scientific community.

His contributions were not only technically remarkable but also deeply meaningful. By enhancing our ability to predict hurricanes, Dodge’s research has undoubtedly preserved lives and lessened the economic burdens of these storms. His legacy resonates with dedication, innovation, and an unyielding quest for knowledge in the face of nature’s mightiest forces.

### A Final Homage: Ashes in the Heart of a Hurricane

In a fitting homage to a life devoted to the study of hurricanes, Dodge’s ashes were scattered into the eye of a [historic Category 5 hurricane](https://arstechnica.com/science/2024/10/hurricane-milton-becomes-second-fastest-storm-to-reach-category-5-status/) in 2023. The storm, Hurricane Milton, rapidly escalated to Category 5 strength, marking it as one of the swiftest storms to achieve such intensity. The symbolic act of releasing Dodge’s ashes into the storm’s eye served as a poignant tribute to his lifelong commitment to understanding these complex meteorological events.

As Jeremy DeHart, a NOAA Hurricane Hunter and Dodge’s colleague,

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Time-Lapse Records Hurricane Milton from the International Space Station

**Incredible Time-Lapse Displays Hurricane Milton from the International Space Station**

As Hurricane Milton makes its way toward Florida, it has captured the interest of meteorologists, citizens, and even astronauts on the International Space Station (ISS). A breathtaking time-lapse video of this immense storm was recently released, highlighting the vast size and strength of the hurricane as it nears the Sunshine State.

### A Storm of Grand Scale

Hurricane Milton has been in the news due to its swift intensification. Starting as a Category 1 storm, it soon surged to a Category 5 hurricane, the highest rating on the Saffir-Simpson scale. This rapid uptick has raised alarms about the possible devastation it could cause along Florida’s coastline, which is still in recovery mode from previous hurricanes like Helene.

The time-lapse footage, filmed by astronaut Matthew Dominick onboard the ISS, provides an aerial view of the hurricane’s rotating clouds and colossal eye. Lasting only 21 seconds, the clip delivers a distinctive viewpoint on the storm’s magnitude, with the ISS orbiting around 250 miles above the planet. From this position, the vast scope of the hurricane becomes strikingly clear, as it stretches hundreds of miles across the ocean.

### The Effects on Florida

Hurricane Milton is projected to hit Florida on Wednesday, with meteorologists forecasting storm surges that could reach up to 15 feet in some regions, especially near Tampa. These surges, along with the hurricane’s fierce winds, might lead to significant flooding and destruction in coastal regions.

The impending storm has already set off a chain reaction affecting multiple sectors. For example, NASA had to postpone the launch of its Europa Clipper mission, originally set to launch from the Kennedy Space Center. The agency pointed to safety concerns due to the storm’s closeness to the launch site.

### A View from Above

The impressive time-lapse video of Hurricane Milton was posted on a well-liked Reddit forum, where it quickly attracted attention. While the initial post did not mention who recorded the footage, NASA later verified that it was taken by astronaut Matthew Dominick from the window of the Dragon Endeavor spacecraft, currently docked with the ISS.

This marks not the first occasion that astronauts aboard the ISS have documented remarkable footage of Earth’s weather phenomena. The unique perspective offered by the space station permits a thorough examination of large weather events, supplying valuable information for researchers and a captivating display for the public.

### The Aftereffects of Hurricane Helene

Florida is accustomed to hurricanes, and the state is still recovering from the destruction caused by Hurricane Helene earlier this year. The arrival of Milton poses a risk of worsening conditions, with many coastal regions already weakened due to previous storm damage. Officials have urged residents in high-risk areas to evacuate, and emergency services remain on high alert as the storm approaches.

### Summary

As Hurricane Milton continues its journey toward Florida, the time-lapse video from the ISS stands as a powerful reminder of nature’s might. The footage not only accentuates the enormity of the storm but also emphasizes the necessity of being prepared for such natural calamities. While the complete impact of Milton is yet to be determined, it is hoped that residents have taken the essential steps to ensure their safety during the hurricane’s arrival.

For those wanting to view the time-lapse video, it has circulated widely on social media and can be found on NASA’s official channels. As always, it’s crucial to stay informed and follow the guidance of local officials during severe weather events like Hurricane Milton.

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